Studies have shown that elevated blood glucose levels may be linked to an older appearance. We've made so many advances in dermatology, but there are some conditions that no cream, pill, or laser treatment can help. For some conditions, you have to work from the inside out. One of my patients was a young woman in her 20s. She was overweight, but certainly not obese. She came to me for darkening and thickening of the skin on the sides of her neck and under her arms that had